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Not all patients will experience gabapentin side effects, and most will feel only the milder effects of gabapentin use when they go on a prescribed regimen. But taking higher doses of gabapentin, or taking it for very long periods of time, increases the severity of the side effects. According to WebMD, these can be anything from swelling in the hands and feet to extreme mood swings (ranging from mania to depression, with suicidal thoughts). Some patients experience short-term memory loss and mental disorientation while others note generalized pain, usually concentrated in the stomach.
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